GH axis

Dosing GHRPs The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg. What that means…

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Beware taking MTII with CJC-1295/GHRP-6 seems to prolong and intensify nausea. (Sample of two at the moment... one of them being me.) Beware GHRP-6 (assume all…

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Joint Regulation of Pulsatile GH Secretion by Estradiol, Dihydrotestosterone and Abdominal Visceral-Fat Mass in Healthy Older Men: A Paradigm of Aromatase and 5-alpha-Reductase Types I and…

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I've tried to emphasize that Slow Wave Sleep (SW) and Growth Hormone (GH) are not merely positively correlated but are intricately bound together such that a…

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Partial explanation (Oct 21, 2009) "Cell-to-cell communication is also likely to reflect the density and proximity of adjacent cells as GH responsiveness (but not sensitivity) to…

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Growth Hormone Secretagogues In the 1980's three classes of compounds where studied to determine their effect on growth hormone release. These three compounds were: Growth Hormone…

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What is a peptide? Peptides (proteins) are present in every living cell and possess a variety of biochemical activities. Some peptides are synthesized in the ribosomes…

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Three Basic Hormones If you form a V w/ your fingers you have the basics for the GH releasing system modeled before you. One finger is…

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Glucose is an indispensable metabolic fuel for the brain. For the reason that the brain is unable to synthesize glucose or store more than a few…

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To quickly summarize the difference in function, MGF stimulates muscle stem cells (satellite cells) to reenter the cell cycle and proliferate, whereas IGF-1 is necessary for…

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EasyEJL your mind is just wasted when it is mixed in with all the "fluff" posts at AM. You mentioned something that to my mind is…

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ESTROGEN Well DHEA conversion to estrogen has a pronounced positive effect on GH. But I wonder...if you have a big fat pad & are an older…

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In plain language, GH in certain circumstances increases glucose uptake identical to that of insulin into both muscle and adipose tissue. This involves translocations of glut…

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I have always maintained that GH signaling activity in muscle or autocrine/paracrine IGFs in muscle are more important then circulating systemic levels. Well here is support…

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The following is the majority of the discussion from, EXPERIMENTAL STUDY - Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of…

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We have spent a lot of time in this thread discussing how GHRPs (such as GHRP-6, GHRP-2, Hexarelin & Ipamorelin) potentiate GHRH's GH releasing effect. We…

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Units of Measurement Growth Hormone (GH) like other biologically active substances is measured in International Units (abbreviated as IU) which are based on the measured biological…

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The following was originally created primarily for my benefit and serves as a basic summary of Growth Hormone Receptor structure, post-biogenesis behavior and degradation. It is…

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This study * caught my attention because it examined the pharmacokinetics of GHRP-2 and in so doing compared it to synthetic GH administration. Basically they found…

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The following was a nice little concise summation of the effect insulin has on GH, GHRs and intracellular events, put together about 6 months back. It…

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Here is evidence that there are set-points for hormones which can change based on environmental factors. It is very interesting that these environmental events can shift…

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The growth hormone secretagogues (GHS) are a family of synthetic compounds originally selected for their potent and specific effects on GH release. Nonetheless, it has been…

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You see people on boards making all sorts of silly claims concerning how many ius we normally secrete. Did anyone catch the chart I posted in…

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I think it's important to start off by visualizing an interesting distinction between peptide hormones such as insulin and growth hormone and the peptide hormone IGF-1.…

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To quickly summarize the difference in function, MGF stimulates muscle stem cells (satellite cells) to reenter the cell cycle and proliferate, whereas IGF-1 is necessary for…

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I am tired of seeing the same wrong explanations on why insulin & growth hormone are anabolic so lets take a look. I don't feel like…

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NOTE that native GRF(1-29) is native GHRH or GRF(1–44) with the inactive final 15 amino acids removed. It is very important to use ONLY modified GRF(1-29)…

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GHRH (Growth Hormone Releasing Hormone) + GHRP (Growth Hormone Releasing Peptide) = 10 star GH Release (**********) GHRP (Growth Hormone Releasing Peptide aka Ghrelin-mimetic) = 3…

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Too many people have very little idea how the following factors work together in increasing proteinsynthesis and preventing protein breakdown. If they truly understood these things…

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This is an interesting study done in cattle. Apparently cattle get one 2 hour feeding a day. So one hour before the meal GHRH by itself…

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There are two types of sleep, rapid eye movement (REM) and non-rapid eye movement (NREM). Sleep proceeds in cycles composed of four types of stages of…

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Rexanator led me to Testosterone Blunts Feedback Inhibition of Growth Hormone Secretion by Experimentally Elevated Insulin-Like Growth Factor-I Concentration, Johannes D. Veldhuis, Stacey M. Anderson, Ali…

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"I hate people that are gurus because they usually don't know what the hell they are talking about. What I've always tried to do is point…

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Summarised entry: the full text is not hosted here. Reproduction of material from Randy Roach, "Splendid Specimens: The History of Nutrition in Bodybuilding". Rights held by…

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Synthetic Growth Hormone is an artificially created hormone "identical" to the major naturally produced (endogenous) isoform. It is often referred to by its molecular mass which…

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