Historical text by DatBTrue, written between 2008 and 2016 and reproduced verbatim. It records what was argued then; it is not dosing guidance and not medical advice. Read the disclaimer.
I have always maintained that GH signaling activity in muscle or autocrine/paracrine IGFs in muscle are more important then circulating systemic levels.
Well here is support for Ghrelin (assumed the mimetics of GHRPs as well) inducing these important changes.
Ghrelin infusion stimulated endogenous GH secretion, which peaked at t = 60 min …Western blots performed on skeletal muscle biopsies revealed distinct STAT5 phosphorylation in all six subjects 30 min after the endogenous GH burst …
This investigation is also the first to document that ghrelin-induced endogenous GH release translates into Janus kinase/STAT signaling in skeletal muscle. – Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling, Esben Thyssen, Diabetes, December 1, 2008; 57(12): 3205 – 3210