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Reading the evidence
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23/09/2018 7:58 pm
Case 5 — Reading a preclinical paper: what belongs beside the abstract?
Put the species or model, design, comparator and measured endpoint before the interpretation. The reader should be able to see what was observed without relying on the headline.
23/09/2018 8:49 pm
Case 5 — Reading a preclinical paper: what belongs beside the abstract?
Was the analysis prespecified or exploratory, and how was uncertainty reported? Record what the paper states and mark unreported fields instead of assuming good practice.
23/09/2018 9:23 pm
Case 5 — Reading a preclinical paper: what belongs beside the abstract?
Separate the authors’ proposed mechanism from the measurements that support it. A plausible explanation is not automatically a demonstrated pathway.
23/09/2018 9:57 pm
Case 5 — Reading a preclinical paper: what belongs beside the abstract?
A human-benefit claim needs appropriate human evidence. This preclinical note should describe its model and translation limits rather than suggesting a treatment change.
23/09/2018 10:06 pm
Case 5 — Reading a preclinical paper: what belongs beside the abstract?
Check the primary paper, supplementary material and any publisher correction. A review article can help locate sources, but it is not a substitute for verifying the cited observation.
23/09/2018 11:06 pm
Case 5 — Reading a preclinical paper: what belongs beside the abstract?
The corrected summary can be useful without a clinical promise: model, methods, endpoint, uncertainty and remaining questions. Link each material statement to its source location.
23/09/2018 11:17 pm
Case 6 — A correction log that survives the next archive update
Use separate entries for the internal transcription correction and the publisher notice. They have different sources and may affect different claims.
23/09/2018 11:23 pm
Case 6 — A correction log that survives the next archive update
A archive table has a transcription error in a unit label. A later publisher notice also changes a figure. How can the correction history distinguish those two events?
Exercise RESEARCH-02447/6: address this question within its stated limits.
23/09/2018 11:53 pm
Case 6 — A correction log that survives the next archive update
Each entry should retain the date, old text, corrected text, reason and source reference. For a publisher notice, link the notice as well as the original paper.
24/09/2018 12:22 am
Case 6 — A correction log that survives the next archive update
Ask whether the changed figure affects the archive’s interpretation. Updating a citation alone may leave an unsupported conclusion in the opening summary.
24/09/2018 1:32 am
Case 6 — A correction log that survives the next archive update
Keep a visible correction near the affected material and a linked changelog entry. Readers who saved the earlier version should be able to understand what changed.
24/09/2018 1:50 am
Case 6 — A correction log that survives the next archive update
The final note should distinguish corrected data transcription, changed source evidence and revised interpretation. Preserve that distinction in subsequent exports.
24/09/2018 1:55 am
Case 6 — A correction log that survives the next archive update
If the source is not accessible, label the revision pending verification. An unavailable document is not a reason to invent its contents.
24/09/2018 2:28 am
Case 7 — Assay-specific reference ranges: what must travel with a result?
A value has been quoted without units, assay method or reference interval. What would make the discussion interpretable?
Exercise RESEARCH-02447/7: address this question within its stated limits.
24/09/2018 2:46 am
Case 7 — Assay-specific reference ranges: what must travel with a result?
Retain units, method, laboratory interval and collection context in a private clinical record. A forum comparison cannot diagnose a condition; a qualified clinician must interpret individual results.
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