The archive
- A Brief Summary of Dosing and Administration
Dosing GHRPs The saturation dose in most studies on the GHRPs (GHRP-6, GHRP-2, Ipamorelin & Hexarelin) is defined as either 100mcg or 1mcg/kg. What that means…
- A Couple of quick notes:
Beware taking MTII with CJC-1295/GHRP-6 seems to prolong and intensify nausea. (Sample of two at the moment... one of them being me.) Beware GHRP-6 (assume all…
- Adipose Visceral Fat Negatively correlated with effectiveness of GHRH & GHRP-2
Joint Regulation of Pulsatile GH Secretion by Estradiol, Dihydrotestosterone and Abdominal Visceral-Fat Mass in Healthy Older Men: A Paradigm of Aromatase and 5-alpha-Reductase Types I and…
- Age-Related Changes in Slow Wave Sleep and Relationship With Growth Hormone Levels
I've tried to emphasize that Slow Wave Sleep (SW) and Growth Hormone (GH) are not merely positively correlated but are intricately bound together such that a…
- Basic Guide: CJC-1295
Partial explanation (Oct 21, 2009) "Cell-to-cell communication is also likely to reflect the density and proximity of adjacent cells as GH responsiveness (but not sensitivity) to…
- Basic Guide: Growth Hormone Secretagogues
Growth Hormone Secretagogues In the 1980's three classes of compounds where studied to determine their effect on growth hormone release. These three compounds were: Growth Hormone…
- Basic Peptide Primer
What is a peptide? Peptides (proteins) are present in every living cell and possess a variety of biochemical activities. Some peptides are synthesized in the ribosomes…
- BEGINNER: What should I use? …and why? (GH Releasing System Simplified)
Three Basic Hormones If you form a V w/ your fingers you have the basics for the GH releasing system modeled before you. One finger is…
- Boosting Insulin Naturally
I understand not wanting to use exogenously administered insulin. Does this mean you would lose out on insulin's contribution to GH induced anabolism? No...you can achieve…
- Caprylic Acid (MCTs) – reduce expression of lipogenic genes
Thank you for posting that up BT. MCTs, specifically caprylic acid (octonate) does much more than that. Permit me to introduce you to one of my…
- CREATING A BACKBONE AROUND WHICH TO LOSE FAT
Glucose is an indispensable metabolic fuel for the brain. For the reason that the brain is unable to synthesize glucose or store more than a few…
- Dat Knows MGF (you might as well learn something as well)
To quickly summarize the difference in function, MGF stimulates muscle stem cells (satellite cells) to reenter the cell cycle and proliferate, whereas IGF-1 is necessary for…
- EOD Calorie Restriction = Longevity?
EasyEJL your mind is just wasted when it is mixed in with all the "fluff" posts at AM. You mentioned something that to my mind is…
- Estrogen – Women & GHRH/GHRP-6
ESTROGEN Well DHEA conversion to estrogen has a pronounced positive effect on GH. But I wonder...if you have a big fat pad & are an older…
- Fish Oil (DHA) increases metabolism (fat loss)
I thought you might be interested in this because almost no nutritionists or people involved in bodybuilding know this. But in the world of aging and…
- Further Note on GH & Insulin
In plain language, GH in certain circumstances increases glucose uptake identical to that of insulin into both muscle and adipose tissue. This involves translocations of glut…
- Ghrelin (assumed GHS) increases GH signalling in muscle
I have always maintained that GH signaling activity in muscle or autocrine/paracrine IGFs in muscle are more important then circulating systemic levels. Well here is support…
- GHRH & GHRP-2 and GH mRNA & GH-R mRNA
The following is the majority of the discussion from, EXPERIMENTAL STUDY - Effect of GHRH and GHRP-2 treatment in vitro on GH secretion and levels of…
- GHRH binds to GHS-receptor & potentiates GHRP’s GH releasing action!
We have spent a lot of time in this thread discussing how GHRPs (such as GHRP-6, GHRP-2, Hexarelin & Ipamorelin) potentiate GHRH's GH releasing effect. We…
- Growth Hormone Administration vs. CJC-1295/GHRP-6 + GHRH
Units of Measurement Growth Hormone (GH) like other biologically active substances is measured in International Units (abbreviated as IU) which are based on the measured biological…
- Growth Hormone Receptor structure, post-biogenesis behavior and degradation
The following was originally created primarily for my benefit and serves as a basic summary of Growth Hormone Receptor structure, post-biogenesis behavior and degradation. It is…
- Here is another way to compare GHRPs & GH dosing vs effect
This study * caught my attention because it examined the pharmacokinetics of GHRP-2 and in so doing compared it to synthetic GH administration. Basically they found…
- Here is the Insulin Cheat Sheet I put together in September
The following was a nice little concise summation of the effect insulin has on GH, GHRs and intracellular events, put together about 6 months back. It…
- Hormonal Set-Points
Here is evidence that there are set-points for hormones which can change based on environmental factors. It is very interesting that these environmental events can shift…
- How GHRPs are cardio-protective
The growth hormone secretagogues (GHS) are a family of synthetic compounds originally selected for their potent and specific effects on GH release. Nonetheless, it has been…
- How much GH do we secrete in IUs?
You see people on boards making all sorts of silly claims concerning how many ius we normally secrete. Did anyone catch the chart I posted in…
- IGF-1 – Primer part 2 (IGF-1 as a regulator of Skeletal Muscle Hypertrophy and Atrophy)
Let's start simply. Hypertrophy results from an enlargement. It is an increase in the size of something that exists and in regard to hypertrophy in skeletal…
- IGF-1, GHRP, Testosterone, Trenbolone & Nandrolone Primer [entire thread…] (What you should read if you don’t want to be a beginner)
I think it's important to start off by visualizing an interesting distinction between peptide hormones such as insulin and growth hormone and the peptide hormone IGF-1.…
- INFO ON MGF USE
To quickly summarize the difference in function, MGF stimulates muscle stem cells (satellite cells) to reenter the cell cycle and proliferate, whereas IGF-1 is necessary for…
- Insulin, how it works and why GH isn’t anabolic w/o it
I am tired of seeing the same wrong explanations on why insulin & growth hormone are anabolic so lets take a look. I don't feel like…
- Modified GRF(1-29) is different then GRF(1-29)
NOTE that native GRF(1-29) is native GHRH or GRF(1–44) with the inactive final 15 amino acids removed. It is very important to use ONLY modified GRF(1-29)…
- PEPTIDES BASICS
GHRH (Growth Hormone Releasing Hormone) + GHRP (Growth Hormone Releasing Peptide) = 10 star GH Release (**********) GHRP (Growth Hormone Releasing Peptide aka Ghrelin-mimetic) = 3…
- Protein Metabolism – The complementary role of various hormones in inducing Anabolism
Too many people have very little idea how the following factors work together in increasing proteinsynthesis and preventing protein breakdown. If they truly understood these things…
- Revisiting peptide timing, meals and GH release
This is an interesting study done in cattle. Apparently cattle get one 2 hour feeding a day. So one hour before the meal GHRH by itself…
- STUDY: Effect of intermittent fasting and refeeding on insulin action in healthy men
Eight healthy young Caucasian men, body mass index 25.7 +- 0.4 kg/m2 Throughout the intervention, the subjects were instructed to uphold their normal exercise habits, to…
- SWS & GH release
There are two types of sleep, rapid eye movement (REM) and non-rapid eye movement (NREM). Sleep proceeds in cycles composed of four types of stages of…
- Testosterone blunts IGF-1 inhibition of GH
Rexanator led me to Testosterone Blunts Feedback Inhibition of Growth Hormone Secretion by Experimentally Elevated Insulin-Like Growth Factor-I Concentration, Johannes D. Veldhuis, Stacey M. Anderson, Ali…
- THE EFFECTS GH AND INSULIN
"I hate people that are gurus because they usually don't know what the hell they are talking about. What I've always tried to do is point…
- The History of Nutrition (supplements & Steroids) in Bodybuilding
Summarised entry: the full text is not hosted here. Reproduction of material from Randy Roach, "Splendid Specimens: The History of Nutrition in Bodybuilding". Rights held by…
- THE SCIENCE BEHIND: ‘SYNTHEROL – SITE ENHANCING OIL’
Summarised entry: the full text is not hosted here. Synthetek Industries, 2009. Rights held by the manufacturer.
- THE SCIENCE BEHIND: ‘SYNTHETINE – LIPID (FAT) TRANSPORTER’
Summarised entry: the full text is not hosted here. Synthetek Industries, 2009. Rights held by the manufacturer.
- What is growth hormone?
Synthetic Growth Hormone is an artificially created hormone "identical" to the major naturally produced (endogenous) isoform. It is often referred to by its molecular mass which…