Reading prompt: the V and Y model in the beginner guide

The archived BEGINNER: What should I use? piece builds the whole GH system out of a V and a Y: GHRH and somatostatin converging on the somatotroph, ghrelin arriving from the stomach to change the arithmetic. It is a teaching model, not a claim about anatomy.

Where does it break down? Pulsatility, sex steroids, sleep architecture and adiposity all move the numbers, and the piece knows it. If you have read the newer literature on ghrelin receptor signalling, this is the thread to argue with the model rather than the man.