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Case 40 — Assay-specific reference ranges: what must travel with a result? · source wording exercise Method note for “Assay-specific reference ranges:...

Keep the source citation, retrieval date and a record of conversions or exclusions. Make synthetic examples explicit and never combine them silently w...

Limit of the answer in “Exploratory subgroup analysis: keep the label visible”: “State whether it was prespecified and how…” is an excerpt from the di...

Case 24 — An evidence table with room for negative findings Limit of the answer in “An evidence table with room for negative findings”: “Include all p...

Explain the study’s scope and limitations without recommending a treatment change. Individual decisions belong with a qualified clinician who can asse...

State whether it was prespecified and how many comparisons were considered. Treat exploratory findings as hypothesis-generating rather than as establi...

Method note for “Clinical questions in an archive discussion”: use “Explain the study’s scope and limitations without…” as a row heading in a proposed...

Ask whether assay, instrument, units or reference intervals changed and retain both original reports. Do not infer a physiological trend before assess...